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Although the exact physiological role remains under study, DSIP has been associated with modulation of hypothalamic and pituitary activity in experimental models

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[PUBMED Abstract] Soura E, Eliades PJ, Shannon K, et al.: Hereditary melanoma: Update on syndromes and management: Emerging melanoma cancer complexes and genetic counseling

Based on our prior experience, 22 NanoBiT strategy 23,24 was used in this study to stabilize the GLP-2GLP-2RG s complex and strengthen the interactions between GLP-2R and G, resulting in a cryo-EM structure at a global resolution of 3.0 (Supplementary information, Table S1)