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RECOMENDACIONES: Precauciones de uso: No se recomienda la administracin de dosis altas durante periodos largos en pacientes con disfuncin renal grave 0 enfermedad renal en fase terminal y sometidos a dilisis, ya que puede producirse una acumulacin en la sangre de los principales metabolitos potencialmente txicos, como son trimetilamina (TMA) y trimetilamina N-xido (TMAO), ya que son excretados en orina normalmente