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Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

The resulting pellet was re-suspended in minimal 50 mM HEPES pH 8.0, 200 mM NaCl, applied to a 1545% w/v sucrose gradient and subjected to ultracentrifugation at 4 C for 3 h, 105,000 g