Triapine - CAS# 143621-35-6 0264 ISRIB potently reverses the effects

ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM)

it was shown and used to enhance the survival and cloning efficiency of many primary cell types after single cell dissociation without affecting their self-renewal properties

(2007) Nat Biotech 25: 681-686

116(9):1524-7

Triapine - CAS# 143621-35-6 0264 ISRIB potently reverses the effectsTriapine, also known as 3 AP and OCX 191, CAS No. 143621 35 6, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. Product information CAS Number: 143621 35 6