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Bipolar disorder similarly exhibits disruption of the Firmicutes / Bacteroidetes ratio and reduced -diversity, featuring increased Streptococcaceae and Bacteroidaceae abundance contrasting with depletion of anti-inflammatory commensals such as Faecalibacterium ( 249).Among neurodegenerative disorders, Parkinsons disease shows increased abundance of Lactobacillus and Bifidobacterium with concurrent reduction in Faecalibacterium , Coprococcus , and Blautia ( 250, 251), where decreased Blautia abundance correlates with clinical severity and reduced fecal butyrate levels (252)

1) UK recommended treatment for B12 deficiency without neuro symptoms is

Immunohistochemical analysis displayed that metformin did not reduce MMP13 expression and only partially decreased ADAMTS5 levels, and Collagen II in Nrf2 KO mice were not significantly influenced by metformin treatment (Fig