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Considering that the water molecules were trapped largely in the hydrophobic pockets, often made contacts with or were displaced by the fragments, and did not appear to play a structural role, we anticipated that their displacement with larger non-polar moieties would improve binding of newly designed inhibitors

In 1459 whole Kodzko Land was elevated by Bohemian king George of Podbrady to the status of county thus the city became a seat of Count (for most of time ruler of Bohemia itself) and local Diet but still remained integral part of Bohemia as "outer region" (Czech: vnj kraj Vladislaus Jagiellon stayed in the city before his coronation as King of Bohemia in Prague

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Mintzer DM, Andreeff M , Filippa DA, Jhanwar SC, Chaganti RS, Koziner B