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14.4 Additional Clinical Studies in Adults with Diabetes Type 1 and Type 2 Different Timing of Insulin Glargine Administration in Diabetes Type 1 and Diabetes Type 2 The safety and efficacy of once daily insulin glargine administered either at pre-breakfast, pre-dinner, or at bedtime were evaluated in a randomized, controlled clinical study in adult patients with type 1 diabetes (Study H, n = 378)

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Finally, in a small trial utilising magnetic resonance spectroscopy (EXENDA) no significant changes were evident in hepatocellular lipids or visceral adiposity between patients receiving combination treatment with exenatide plus dapagliflozin and those treated with dapagliflozin alone [13]

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