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Haematological Isolated red cell macrocytoisis Macrocytic anaemia (especially if MCV more than 110fl) Pancytopenia (especially if MCV more than 120fl) Neurological or Psychiatric Optic neuropathy Peripheral neuropathy (sensory or motor) Symmetrical neuropathy affecting the legs more than the arms

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Another study showed that after 26 weeks of treatment with a different GLP-1 receptor agonist (liraglutide), people had improvements in their mental health and energy levels, compared to people who received a placebo.

Interventions like calorie restriction that nudge mTOR into the repair mode have been shown to extend lifespan in yeast, worms, flies, and mice [8]