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Rare complications, such as gallbladder issues or pancreatitis, may also arise

You can also see that our cover on TNDM was quite well timed, I actually may consider putting that short back on now

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Concurrently, mitochondrial ROS (mtROS) amplifies vascular dysfunction by oxidizing BH4, uncoupling endothelial eNOS, and reducing NO bioavailability while also activating pro-inflammatory pathways (e.g., NLRP3 inflammasome) and stimulating NOX activity, creating continuous oxidative damage (Penna and Pagliaro, 2025)