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doi: 10.1016/j.isci.2024.110864 26 GuoLZhaoYBaiXWangXTuohetiKCaoYet al

Because of this hormone decline, most types of hormone replacement therapy (HRT, now commonly referred to as menopause hormone therapy, or MHT) use a form of estradiol

This means that while your body can usually produce enough of it on its own, there are timessuch as during periods of high physical stress, intense exercise, or recoverywhen your bodys demand for it may exceed its ability to produce it