Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing suppressed by proinflammatory mediators like

suppressed by proinflammatory mediators like lipopolysaccharide (LPS)| Interferon gamma/IFNG| and tumor necrosis factor alpha

Translocation of this gene with the MLL gene is associated with secondary acute leukemia

including those that encode for chemokines

This gene is a member of the metallocarboxypeptidase gene family

Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 20ul Gene Editing suppressed by proinflammatory mediators likeThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF beta receptor type 1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding