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Key Takeaways Gradual dose escalation over 20 weeks minimizes gastrointestinal side effects while building therapeutic efficacy Standard monotherapy reaches a maximum maintenance dose of 4.5 mg weekly after systematic increases Combination protocols (CagriSema) pair cagrilintide with semaglutide for enhanced weight management outcomes Clinical trial data demonstrates approximately 10.8% body weight reduction with monotherapy at 32 weeks Proper injection technique and site rotation are essential for optimal absorption and safety Understanding Cagrilintide: What Health Professionals Need to Know Cagrilintide is a long-acting amylin analogue currently being developed by Novo Nordisk for obesity and type 2 diabetes management

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The following is the typical dosing schedule for weeks 5-16: Weeks 5-8: 0.5 mg (semaglutide) / 0.5 mcg (vitamin B12) once weekly Weeks 9-12: 1.0 mg (semaglutide) / 0.5 mcg (Vitamin B12) once weekly Weeks 13-16: 1.7 mg (semaglutide) / 0.5 mcg (Vitamin B12) once weekly Weeks 17 onwards: 2.5 mg (semaglutide) / 0.5 mcg (Vitamin B12) once weekly, if further weight loss is required

If you fall into any of these risk categories, discuss B12 testing with your GP or midwife early in pregnancy