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This receptor regulates growth hormone release directly by stimulation and indirectly by a feedback relationships with somatostatin

As such, this can cause an increased susceptibility to many age-related conditions and diseaseswhich includes the aging process itself, metabolic deficiencies, as well as chronic age-related diseases, such as cataracts, hearing impairment, and glaucoma, to name a few

neurexin-1 expression level increases with age, neurexin-3 remains stable, and neurexin-2 expression level is higher than that of neurexin-1 and neurexin-2 at early ages [66]