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The significant ways to improve the quality of the preconception phase are to improve nutritional status.1 Nutrition is associated with increasing the cortisol hormone as a physiological response to stress that is secreted by the adrenal cortex.24 Working women, during menstruation, pregnancy, childbirth, postpartum, and menopause, are more likely to experience stress up to two times more than men.2,5,6 Glutathione hormone is related to oxidative stress

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De-escalation strategies in HER2positive early breast cancer (EBC): final analysis of the WSG-ADAPT HER2+/HR- phase II trial: efficacy, safety, and predictive markers for 12 weeks of neoadjuvant dual blockade with trastuzumab and pertuzumab +/- weekly paclitaxel