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Vermeire S, Rutgeerts P: Current status of genetics research in inflammatory bowel disease

10.1016/0024-3205(92)90504-I 35 ZhangL.FallaT

Tirzepatide activates two receptors both GLP 1 and GIP (glucose dependent insulinotropic polypeptide)

Mutations found in the MRP6 gene are associated with genetic abnormalities of the autosomal inherited connective tissue disorder called pseudoxanthoma elasticum (PXE), which is characterized by the presence of dystrophic elastic fibers in the skin, retina, and large blood vessels, causing the appearance of bags in the skin, loss of vision and calcification of blood vessels [100]