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Sulforaphane inhibits oxidative stress and may exert anti-pyroptotic effects by modulating NRF2/NLRP3 signaling pathway in Mycobacterium tuberculosis -infected macrophages

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The first step is rate-limiting and subject to feedback inhibition by glutathione itself, holding intracellular concentrations in the low millimolar range, typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999