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In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class

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"It also points to the need for better strategies to make these treatments more accessible and available to those who need them.However, researchers noted that larger studies involving more women are needed to confirm their findings and figure out why hormone therapy might boost GLP-1 drug effectiveness.Findings presented at medical meetings should be considered preliminary until published in a peer-reviewed journal.More information The Mayo Clinic has more on menopause hormone therapy.SOURCE: The Endocrine Society, news release, July 12, 2025 .What This Means For YouWomen should talk to their doctor about using menopause hormone therapy and GLP-1 drugs..Sign up for our weekly HealthDay newsletter