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There are some dramatic left-tail-risk scenariosfor example, all people with above-average body mass index (BMI) take GLP-1 medications and stick to the prescribed regimen (including changing food habits per doctor recommendations) for a prolonged period

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Bersuker K, Hendricks JM, Li ZP, Magtanong L, Ford B, Tang PH, Roberts MA, Tong BQ, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA

As glutathione levels decline with age, stress, alcohol consumption, and environmental exposure, the liver's detox capacity decreases leaving cells more vulnerable to the oxidative byproducts of everyday life