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JAMA Intern Med 184(9):10561064 Zhang M, Lin C, Cai X, Jiao R, Bai S, Li Z et al (2025) One or two

When semaglutide was placed on the Drug Shortage List in 2022, state-licensed pharmacies, physicians, and qualified outsourcing facilities could legally produce it without facing typical compounding restrictions imposed by the FDA

And serious side effects in clinical trials have been rare

While GLP-1 drugs represent a ground-breaking leap in treating metabolic disorders, their casual over-the-counter sale invites widespread misuse and the possibility of severe side effects