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Figure 2 4.1 High expression of all three key SSP enzymes: PHGDH, PSAT1 and PSPH 4.1.1 Non-small cell lung cancer In non-small cell lung cancer (NSCLC), the expression of PHGDH, the rate-limiting enzyme of the SSP, is significantly higher in tumor tissues than in adjacent normal tissues, and is positively correlated with TNM stage