FILA2 Rabbit Polyclonal Antibody, 100ul Molecular Sciences The protease consists of two

The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene

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Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins

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FILA2 Rabbit Polyclonal Antibody, 100ul Molecular Sciences The protease consists of twoThe filaggrin like protein encoded by this gene is upregulated by calcium proteolyzed by calpain 1 and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact in addition to providing a physical barrier C terminal fragments of this protein display antimicrobial activity