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No, nightmares are not listed as a recognised side effect in the MHRA-approved prescribing information for Wegovy, and large-scale clinical trials have not identified sleep disturbances as a significant adverse event

and Burastero, S.E., 2015

So blocking histamine is the mechanism of action

Healthcare providers are increasingly utilizing GLP-1 receptor agonists to improve glycemic control while reducing cardiovascular risks and supporting weight management goals