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It reflects the combination of rapid weight loss, reduced caloric intake, and metabolic adjustment rather than any direct toxic effect of the compound

This delayed gastric emptying is part of how the drug helps people feel fuller for longer, but it can also change the timing of absorption for pills taken around the same time

[PubMed ID: 31118852]

[14] Whether Ipamorelins comparatively selective profile shares that appetite effect to any meaningful degree is not well characterized, but the possibility is one more reason the before-sleep timing model cannot be treated as a settled, consequence-free choice