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Native GLP-1 has a short half-life due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) ( Figure 1 In recent years, growing evidence has highlighted a bidirectional interplay between GLP-1 RAs and the gut microbiome

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By enhancing satiety, appetite control, and energy balance, they support clearer, more logical decision-making around food and daily habits