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Moreover, microgravity also steers mechanical unloading of the endothelial cells, altering their cytoskeletal structure through RhoA-dependent rearrangement of the actin cytoskeleton 8,9

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Before the targeted synthesis and isolation of these peptides, research into tissue recovery and regenerative processes relied heavily on generalized growth factors and less specific biological agents