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Although traditionally considered an inflammatory disorder of white matter, more recently it has become apparent that gray matter damage is also prominent and widespread, though the immune responses are less pronounced in this region, and therefore the radiological and pathological signatures more subtle

The close ECD-TMD interaction in the apo-state is reminiscent of the state in the recent structure of the smoothened receptor, which shows extensive interactions of its ECD with the ECLs of its TMD [45]

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Brand-Name GLP-1s Differ in Practice Compounded semaglutide and tirzepatide contain the same active pharmaceutical ingredient (API) as their brand-name counterparts