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Patients in their 40s, 50s, and 60s often hit a metabolic wall: weight gain that did not happen at 30, fasting glucose climbing into the high-90s or low-100s, fatigue that does not match their workload, and a feeling that their body is no longer responding to the things that used to keep them lean

This convergent evidence led us to hypothesize that the LS might serve as a neuroanatomical substrate mediating tirzepatides effects on mesolimbic dopamine signaling and alcohol-related responses

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