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doi:10.1016/j.amjmed.2009.03.015 Kooy A et al (2009): Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus

They focus on FDA-approved uses for medications

A statistically robust, dose-dependent decrease in the very biomarkers that drive autoimmune disease activity

Managing Side Effects at Each Dose Side effects follow predictable patterns, typically peaking within a few days of dose increases then improving substantially