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These methylation reactions also regulate gene expression during fetal development

It remains a research chemical, and its use in humans is primarily limited to clinical studies, though it is not universally banned

Incidentally, the healthy reference range is 191-663 pg/ml and correlates closely with oral cobalamin intake, which is why the vitamin B12 blood level alone is not an adequate parameter to diagnose a deficiency (Herrmann and Obeid, 2014)