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In view of the varying society guidelines, clinicians must still weigh several factors when deciding how to manage ACE inhibitors and ARBs in the perioperative setting: Because of the potential risks associated with withholding ACE inhibitors and ARBs, along with emerging evidence suggesting no significant harm from their continuation, current cardiovascular society recommendations increasingly support maintaining these medications

Despite these advancements, both Rhythm Pharmaceuticals and Palatin Technologies report focusing their agonist programs on treating monogenic or syndromic obesity populations (130, 134)