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A limitation with the use of GLUTag cells, as well as other models for epithelial cells, is that the cells have lost their polarization, which may affect the amino acid sensing mechanisms, as different amino acid transporters are situated on the apical compared to the basolateral membrane [28]

Fast-forward to today, and BPC-157 is embroiled in controversy

Whether that specificity translates to superior clinical outcomes remains to be proven through rigorous trials

In a Spanish study evaluating 32 prospectively gathered ALI cases, the APAP-associated Roussel Uclaf Causality Assessment Method (RUCAM) score was higher compared to that of other concomitant medications