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A, D, and E can accumulate to harmful levels

Limitations of this review This review systematically summarizes the pharmacokinetic basis, multi-organ toxicity mechanisms, chemoresistance link, clinical challenges, and intervention strategies of in vivo platinum accumulation from platinum-based chemotherapeutics

Protocol 4: nasal spray approach Goal: Needle-free administration with acceptable bioavailability trade-off Duration: 20 days active, then 4-6 months off Schedule: Days 1-20: 10-15 mg epitalon intranasally, divided into 2-3 daily doses Days 21-180: Off cycle Repeat 1-2 times per year Formulation: Reconstitute in saline with 3 percent DMSO for improved nasal absorption