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Additionally, increasing studies have revealed the important mechanisms in the communication of mitochondria with other parts of cells (16), including cytochrome c release to induce cell death, 5-adenosine monophosphate-activated protein kinase activation to control mitochondrial fission and fusion, ROS generation to activate transcription factors, and mtDNA release to activate immune responses (Figure 1)

The role of oxidative stress in atopic dermatitis