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UK hydration guidelines recommend: Aim for at least 1.5-2 litres daily: Roughly 8 glasses of water Increase intake by 500ml on days when you experience digestive side effects Set reminders to drink regularly, as appetite suppression may reduce thirst signals Watch for dehydration signs: Darker urine, dry mouth, fatigue, or dizziness Many patients find carrying a marked water bottle helps them track intake, especially when appetite cues are reduced by medication

Hypothesis: Replication of Phase 2 results (24 %) in a larger population over a longer duration

Some people reduce fluid intake because nausea makes drinking uncomfortable

As these therapies become more widespread, physicians are tasked with balancing profound weight loss against the potential for sarcopenia and long-term frailty