LY2603618 alog-1 Wahiduzzaman M

Wahiduzzaman M

ML-329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation

InChi: InChI=1S/C39H37F6N3O2

Eliminating cells gone astray

LY2603618 alog-1 Wahiduzzaman MRabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP dependent serine threonine kinase, is a key component in the DNA replication monitoring checkpoint