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Supercooling prevents the accumulation of free fatty acids and consumption of acyl-carnitines Storage-induced and oxidant stress-dependent activation of phospholipase A2 (PLA2) or PLA2-like enzymes such as peroxiredoxin 6 50,51 has been observed during RBC storage and represents a hallmark of storage-induced lipid peroxidation (Fig

Accordingly, these evidences prove the hypothesized that Nrf2 can regulate intracellular iron metabolism through the Nrf2HO-1 axis pathway to regulate ferroptosis

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Replication studies should integrate a positive control (e.g., memantine, donepezil) to validate the paradigm