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Controlled mechanical loading through gradual weight-bearing activities helps condition the repaired tissue, stimulating chondrocyte proliferation and ECM production while ensuring proper integration and function

[9] Bone remodeling markers rise before density itself changes, so this was an early biomarker signal rather than proof of fracture-relevant benefit a distinction reinforced by the hip-fracture trial discussed below, which failed to show functional benefit

Ethylhexyl Palmitate, Sorbeth-30 Tetraoleate, Isopropyl Palmitate, Cetyl Ethylhexanoate, Triethylhexanoin, Diisostearyl Malate, Caprylic/Capric Triglyceride, Sorbitan Sesquioleate, Argania Spinosa Kernel Oil, Glycine Max (Soybean) Oil, Glycine Soja (Soybean) Oil, Hippophae Rhamnoides Fruit Oil, Oryza Sativa (Rice) Bran Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Punica Granatum Seed Oil, Pyrus Malus (Apple) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Water, Camellia Japonica Seed Oil, Citrus Junos Fruit Oil, Glutathione, Niacinamide, Panax Ginseng Seed Oil, Butylene Glycol, Adansonia Digitata Seed Oil, Camellia Oleifera Seed Oil, Carthamus Tinctorius (Safflower) Seed Oil, Centella Asiatica Extract, Helianthus Annuus (Sunflower) Seed Oil, Hippophae Rhamnoides Oil, Olea Europaea (Olive) Fruit Oil, Persea Gratissima (Avocado) Oil, Prunus Armeniaca (Apricot) Kernel Oil, Ribes Nigrum (Black Currant) Seed Oil, Caprylyl Glycol, Ethylhexylglycerin, 1,2-Hexanediol, Fragrance

The authors hypothesized that Vit B12 has an important role in the metabolism of homocysteine, increased levels of which are responsible for the loss of pigment due to deficient methionine synthesis