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And I also see period changes that isn't, I have not found that in the literature

Well-documented data At standard doses, vitamin B6 and B12 are generally well tolerated, though high doses of B6 over time can cause nerve damage (sensory neuropathy)

Regarding cardiometabolic risk factors, both groups observed a reduction in resting systolic and diastolic blood pressure and fasting glucose and cholesterol concentrations after the weight reduction period