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Mechanism of Action IGF-1 LR3 binds to insulin-like growth factor-1 receptors on the cell surface, activating intracellular signaling pathways that regulate cell proliferation, survival, and metabolism

This work, by delineating the FA-AA-inflammasome axis and cataloging the mechanism-based interventions, provides a framework for developing precision therapies that simultaneously address metabolic dysfunction and sterile inflammation in GA