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What theyre saying: We believe that inhibiting new pathways on top of GLP-1 receptor agonism has the potential to achieve comparable overall reductions in body weight, but with improved quality of a weight loss, resulting in more fat loss while preserving or actually increasing muscle mass. Regenerons CSO George Yancopoulos The big picture If any of these medications (or combinations of medications) can actually enable people to lose weight while preserving muscle mass, the impact on public health could be huge but itll likely be years before they reach the market

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Figure 1: Mean (SE) Insulin Secretion Rates During Infusion of Exenatide or Placebo by Treatment, Time, and Glycemic Condition in Healthy Subjects SE = standard error

Research suggests the opposite: a 12-week moderate-intensity exercise programme improved muscle strength and reduced fatigue in people experiencing statin-associated muscle symptoms, without worsening those symptoms