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Funding This work was supported by the Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine (to HL) and the Albert B

In controlled laboratory settings, this compound is widely researched for sleep-related pathway activity, neurotransmitter interactions, and circadian signalling mechanisms associated with restorative biological processes

The extended-release (ER) formulation encapsulates exenatide within biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres, which form a polymeric matrix that allows sustained drug release following SC administration [13, 14, 58]